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KMID : 0613319970030020089
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Journal of the Korean Bone and Joint Tumor Soceity
1997 Volume.3 No. 2 p.89 ~ p.97
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Prognostic Factors of Soft Tissue Sarcomas
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Lee Jong-Seok
Jeon Dae-Geun
Lee Soo-Yong
Kim Sug-Jun
Jung Dong-Whan
Park Hyun-Soo
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Abstract
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Twenty hundred and five out of 266 patients who were registered in Korea Cancer Center Hospital from Mar. 1985 to Jan. 1994, were analyzed in the aspect of survival and local recurrence. Fifty one patients were excluded due to inadequate data and follow up. Prognostic factors for survival were evaluated statistically. One hundred and four cases were male, 101 female. Average age was 39.7[range 1 to 77]year with a peak incidence around 4th decade. The most frequent diagnosis was malignant fibrous histiocytoma [MFH][24.1%]. Liposarcoma, synovial sarcoma, rhabdomyosatcoma, malignant peripheral nerve sheath tumor and fibrosarcoma were relatively common diagnostic entities, in decreasing order. In location, extremity was 179[87.3%] and trunk 26[12.7%]. Average follow up period was 7.5 years [6 months to 10 tears]. Actuarial 5 years and 20 years survival tare 64.0% and 40.8% respectively. In univariate analysis with log-lank test, signigicant differences in survival rate were noted in histopathological diagnosis, size[10 cm], stage and metastasis. Age, sex, tumor location, tumor depth and local recurrence didn`t affect the survival rate. Adjuvant chemotherapy and/or radiotherapy did not affect overall survival rate, but lowered the local recurrence rate when compared with surgery only. Surgical margin did not affect the survival rate, but local recurrence rate was different according to each margin; 5.7% in more than wide; 39.5% in marginal; and 60.0% in intralesional excision. In multivariate analysis for results of univariate analtsis with Cox`s propotional model, metastasis was a meaningful factor for survival of soft tissue sarcoma.
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KEYWORD
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Soft tissue sarcoma, Survival, Recurrence, Prognostic factor
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